Emptiness as a human condition is a sense of generalized boredom, social alienation, nihilism and apathy. Feelings of emptiness often accompany dysthymia, depression, loneliness, anhedonia, despair, or other mental/emotional disorders, including schizoid personality disorder, post-traumatic stress disorder, attention deficit hyperactivity disorder, schizotypal personality disorder and borderline personality disorder. A sense of emptiness is also part of a natural process of grief, as resulting death of a loved one, or other significant changes. The particular meanings of "emptiness" vary with the particular context and the religious or cultural tradition in which it is used.

While Christianity and Western sociologists and psychologists view a state of emptiness as a negative, unwanted condition, in some Eastern philosophies such as Buddhist philosophy and Taoism, emptiness (Śūnyatā) represents seeing through the illusion of independent self-nature.